BIOCHEMICAL STUDIES ON CHLORAMPHENICOL (CHLOROMYCETIN)

BIOCHEMICAL STUDIES ON CHLORAMPHENICOL (CHLOROMYCETIN*) III. ISOLATION AND IDENTIFICATION OF METABOLIC PRODUCTS IN URINEt

When chloramphenicol is administered by mouth to normal human subjects, only 5 to 10 per cent of the administered dose is excreted unchanged in the urine, as determined by microbiological assay methods (3, 4). However, with calorimetric methods for aromatic nitro compounds (5), from 75 to 90 per cent of the administered dose is accounted for in 24 hour urinary excretion in man (3). The major po...

Chloramphenicol (chloromycetin), an Antibiotic. Pharmacological and Pathological Studies in Animals.

It is a neutral white crystalline substance with a bitter taste and is stable in neutral and acid solutions. The drug is moderately soluble in water (0.25 per cent at room temperature, 0.65 per cent at 700 C and up to 15 per cent in propylene glycol, 5 per cent in 50 per cent acetamide), and is insoluble in vegetable oils. Solubility in urine or serum is about the same as in water. Solutions ar...

Susceptibility of Micro-organisms to Chloramphenicol (chloromycetin).

Chloramphenicol (chloromycetin) in the Treatment of Tsutsugamushi Disease (scrub Typhus).

The present paper augments information previously published on the first 25 patients with scrub typhus to receive chloromycetin (1) and reviews our experience in the use of this drug in the treatment of a total of 69 persons who contracted tsutsugamushi disease in the vicinity of Kuala Lumpur, Federation of Malaya. The results obtained in this group are compared with those observed in 19 patien...

Preliminary Report on the Use of Chloramphenicol (chloromycetin) in the Treatment of Acute Gonorrheal Urethritis.